Your Lead QSP PK - Project Manager

2023

1. L'Hostis, A., Palgen, J. L., Perrillat-Mercerot, A., Peyronnet, E., Jacob, E., Bosley J. R., Duruisseaux M., Toueg R., Lefèvre L., Kahoul R., Ceres, N. & Monteiro, C. (2023). Knowledge-based mechanistic modeling accurately predicts disease progression with gefitinib in EGFR-mutant lung adenocarcinoma. npj Systems Biology and Applications (accepted).
2. Jacob, E., Perrillat-Mercerot, A., Palgen, J. L., L’Hostis, A., Ceres, N., Boissel, J. P., Bosley J., Monteiro C. & Kahoul, R. (2023). Empirical methods for the validation of Time-To-Event mathematical models taking into account uncertainty and variability: Application to EGFR+ Lung Adenocarcinoma. BMC Bioinformatics (accepted).

2022

1. Palgen, J. L., Perrillat-Mercerot, A., Ceres, N., Peyronnet, E., Coudron, M., Tixier, E., Illigens B., Bosley J., L’Hostis A. & Monteiro, C. (2022). Integration of heterogeneous biological data in multiscale mechanistic model calibration: application to lung adenocarcinoma. Acta Biotheoretica, 70(3), 1-24.
2. Perrillat-Mercerot, A., Deliot, N., Miranville, A., Guillevin, R., & Constantin, B. (2022). Mathematical Analysis of Membrane Transporters Dynamics: A Calcium Fluxes Case Study. Acta Biotheoretica, 70(2), 1-32.

2021

1. Perrillat-Mercerot, A., Miranville, A., Agosti, A., Rocca, E., Ciarletta, P., & Guillevin, R. (2021). Partial differential model of lactate neuro-energetics: analytic results and numerical simulations. Mathematical Medicine and Biology: A Journal of the IMA.

2019

1. Perrillat-Mercerot, A., Guillevin C., Miranville A., & Guillevin R. (2019). Using mathematics in MRI data management for glioma assessment. Journal of Neuroradiology.
2. Perrillat-Mercerot, A., Miranville A., Bourmeyster N., Guillevin C., Naudin M., & Guillevin R. (2019). What mathematical models can or cannot do in glioma description and understanding. Discrete & Continuous Dynamical Systems - S.
3. Perrillat-Mercerot, A., Bourmeyster N., Guillevin C., Miranville A., & Guillevin R. (2019). Analysis of a mathematical model for the glutamate/glutamine cycle. Bulletin of Mathematical Biology, 1-20.
4. Perrillat-Mercerot, A., Bourmeyster N., Guillevin C., Miranville A., & Guillevin R. (2019). Mathematical Modeling of Substrates Fluxes and Tumor Growth in the Brain. Acta Biotheoretica, 1-27.

2018

1. Helal, M., Igel-Egalon, A., Lakmeche, A., Mazzocco, P., Perrillat-Mercerot, A., Pujo-Menjouet, L., Rezaei H., & Tine, L. M. (2018). Stability analysis of a steady state of a model describing Alzheimer’s disease and interactions with prion proteins. Journal of Mathematical Biology, 1-25.
2. Guillevin C., Guillevin R., Miranville A., & Perrillat-Mercerot, A. (2018). Analysis of a mathematical model for brain lactate kinetics. Mathematical Biosciences & Engineering, 15(5), 1225-1242.

2017

1. Guillevin R., Miranville A., & Perrillat-Mercerot A. (2017). On a reaction-diffusion system associated with brain lactate kinetics. Electronic Journal of Differential Equations, 2017(23), 1-16.

🌍 International

• Sept. 2019
  Perrillat-Mercerot A., Investigation on complex nutrient fluxes, International Workshop Mathematical Biology on the Mediterranean Conference (MBMC), Samos (Greece)
• May 2019
  Perrillat-Mercerot A., Substrate fluxes between cells and capillaries, Workshop Recent advances in Phase-Field modeling: from Engineering to Biology, Pavia (Italy)
• July 2018
  Perrillat-Mercerot A., What about lactate kinetics in a (gliomatous) brain?, invited speaker at the special session Recent Advances in Mathematical Biology, Ecology, Epidemiology, and Oncology organized by Sophia Jang, Hsiu-Chuan Wei, Ting-Hui Yang, Jui-Ling Yu and Alain Miranville, The 12th AIMS Conference, Taipei (Taiwan)

🇫🇷 National

• Sept. 2020
  Perrillat-Mercerot A., From MRS data to mathematical equations and back, Internal presentation, Grenoble.
• March 2020
  Perrillat-Mercerot A., Modeling and study of cerebral energy metabolism, Internal presentation, Strasbourg.
• Dec. 2019
  Perrillat-Mercerot A., Use of Mathematics in medical imaging, application to the study of brain tumors, Round table for the 80th anniversary of CNRS - Health division, Poitiers.
• Dec. 2019
  Perrillat-Mercerot A., Models in neuro-oncology, Workshop Oncosphère Nouvelle-Aquitaine, Angoulême.
• June 2019
  Perrillat-Mercerot A., Approach to cerebral lactate fluxes, from 1D to 3D, 39th SFBT Colloquium, Poitiers.
• June 2019
  Perrillat-Mercerot A., Mathematics and glioma, a story of operations., 39th SFBT Colloquium, Poitiers.
• June 2019
  Perrillat-Mercerot A., When mathematics uses operations against gliomas, ANOCEF Congress 2019, Poitiers.
• May 2019
  Perrillat-Mercerot A., How MRI and mathematics can get together, Invited by the University of Pavia, Pavia (Italy).
• Nov. 2018
  Perrillat-Mercerot A., When mathematics uses operations against gliomas, Young Mathematicians Forum, Femmes & Mathématiques, Orléans.
• Nov. 2018
  Perrillat-Mercerot A., What about nutrient kinetics in a (gliomatous) brain?, Invited by Politecnico di Milano, Milan (Italy).
• Nov. 2018
  Perrillat-Mercerot A., What about nutrient kinetics in a (gliomatous) brain?, Invited by University of Pavia, Pavia (Italy).
• Sept. 2017
  Perrillat-Mercerot A., A model for studying tumor growth. Math and cancer day, Poitiers.
• June 2017
  Perrillat-Mercerot A., Reduced model for lactate kinetics. 37th SFBT Colloquium, Poitiers.

🎓 Doctoral

• Feb. 2019
  Presentation during the doctoral students seminar of the SISMI doctoral school in Poitiers.
• Oct. 2018
  Presentation during the doctoral students seminar in Amiens at AMFA in Amiens.
• March 2018
  Presentation at thematic days of the bio-health doctoral school in Cussac.

🧾 Presentations with support (poster & e-poster)

• April 2026
  Patnaikuni N., Luklem T., Srinivas Duddu A., E.S.,2, Kolappurath Madathil A.,*, BC N., Thiagarajan K., Dixit N., Kumar R. Perrillat-Mercerot A., Modeling of efficacy and nausea of GLP-1 mono and dual (GLP-1/GIP) receptor agonists (RA) to support weight management and glycemic control in obese patients, QSP Conference (QSPC), Leiden.
• June 2025
  Chadalavada S.M., Dey S., Pendsey N., Nair G., Packirisamy P., Joshi T., Rengaswamy M., Kumar R., Perrillat-Mercerot A., Build and explore your own mono and combo therapies to Optimize clinical outcomes in IBD, Population Approach Group in Europe (PAGE), Thessalinoki.
• Oct. 2024
  Paleja B., Dutta R., Srinivasan V., Sahoo S., and Kumar R., A quantitative systems pharmacology (QSP) model framework for combined clinical efficacy and hematological toxicity predictions for antibody-drug conjugates, American Conference on Pharmacometrics, Phoenix.
• Oct. 2024
  Perrillat-Mercerot A., Gangwar V., Bhardway A. Raman Aditya K., Sing R., Channavazzala M., Paleja B., A comprehensive multi-scale in silico approach for predicting antibody-drug conjugate clinical efficacy across oncological indications, Groupe de Métabolisme et Pharmacocinétique Meeting, Lyon.
• June 2024
  Perrillat-Mercerot A., Gangwar V., Bhardway A. Raman Aditya K., Sing R., Channavazzala M., Paleja B., A comprehensive multi-scale in silico approach for predicting antibody-drug conjugate clinical efficacy across oncological indications, Population Approach Group in Europe (PAGE), Rome.
• Sept. 2019
  Perrillat-Mercerot A., Bourmeyster N., Miranville A., Guillevin R., Guillevin C. Let’s make maths about lactate in the brain, 23rd ESN Biennial Meeting – 7th Conference on Molecular Mechanisms of Regulation in the Nervous System, Milan.
• March 2018
  Perrillat-Mercerot A., Guillevin C., Guillevin R., Miranville A. Mathematical modeling of intracerebral glutamate fluxes integrating MR spectroscopy data. 45th SFNR Congress, Paris.
• Sept. 2017
  Perrillat-Mercerot A., Guillevin C., Guillevin R., Miranville A. Data Analysis and Computation Through Imaging and Modeling – Maths Image Santé. Francophone Radiology Days – Innovation Village, Paris.
• Sept. 2017
  Perrillat-Mercerot A., Guillevin C., Guillevin R., Miranville A. A model for studying tumor growth. Math and cancer day, Poitiers.
• June 2017
  Perrillat-Mercerot A., Guillevin C., Guillevin R., Miranville A. Dynamics of energy substrates in the brain affected by glioma. Poster – ANOCEF Congress 2017, Nancy.

🎖️ Awards & Grants

• May 2019
  EC2U grant for a laboratory exchange with the University of Pavia (Italy). (EC2U). My report: eng - fr.
• Nov. 2018
  GDR Mamovi grant to present at the Young Mathematicians Forum. (GDR Mamovi)
• Nov. 2018
  LYSM grant for a laboratory exchange with the University of Pavia and the Polytechnic School of Milan (Italy). (LYSM)
• June 2017
  Delattre prize awarded for an oral presentation at the 37th SFBT Colloquium. (SFBT)
• Sept. 2017
  GDR Mamovi grant to attend the GDR Mamovi session. (GDR Mamovi)

🌍 International & Other Activities

• Feb 2025 - Ongoing.
  Member of the ISoP community. Community Manager for the ISoP-Connect.
• March 2023
  Co-organization of a symposium: Credibility and Validation of knowledge-based models.
• 2020/2022
  Member of the editorial board for Acta Biotheoretica.
• Sept. 2022
  Organization of a symposium: Knowledge model creation: Key points and traps.
• Oct. 2021
  Co-organization of a conference: IbOMaN, focus on treatment studies.
• June 2020
  Co-organization of a videoconference: IbOMaN, focus on pre-treatment studies (website).
• Sept. 2019
  International summer school "Mathematical Biology on the Mediterranean Conference (MBMC)", Samos (Greece).
• July 2018
  Summer school "CEMRACS: Numerical and mathematical modeling for biological and medical applications: deterministic, probabilistic and statistical descriptions" in Marseille.
• Dec. 2017
  Winter school "Winter School on Deterministic and Stochastic Models in Neuroscience" in Toulouse.
• Sept. 2017
  GDR Mamovi session (Mathematics of Living Modelling) in Lyon. (GDR Mamovi)